From Apr. 15 to 17, the 25th Joint Conference on Communications and Information (JCCI) was held in Buyeo, Korea. Prof. Hyun Jong Yang and Hyunmyung Oh were invited to give a special talk “5G Multiple-Access: Latency vs. Spectral Efficiency.” In this talk, a new mega trend in the mobile communication toward ultra-low latency was introduced with future killer applications. To achieve the ultimate goal of less than 10ms of the end-to-end latency, problems of the current multiple-access technologies were addressed. In particular, one of the promising multiple-access technologies achieving very low latency, the generalized frequency division multiple-access (GFDMA), is analyzed in two aspects: latency and spectral efficiency. Preliminary results showed that there exists a trade-off between the two aspects.